A Case of Acquired Pulmonary Alveolar Proteinosis Successfully Treated with Whole Lung Lavage

A Case of Acquired Pulmonary Alveolar Proteinosis Successfully Treated with Whole Lung Lavage

Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by the accumulation of surfactant within the alveoli. Surfactant phospholipids and proteins are produced by type II alveolar epithelial cells, and subsequently cleared by the alveolar macrophages. Cell signaling initiated by the g...

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Bibliographische Detailangaben
Hauptverfasser: Borders, Charles W, Morgan,Julie
Format: Report
Sprache:eng
Schlagworte:
alveolar macrophages
alveoli
disease attributes
epithelial cells
GM-CSF(granulocyte- macrophage colony-stimulating factor)
lung
lung diseases
macrophages
pap(Pulmonary alveolar proteinosis)
Pulmonary function
PULMONARY INSUFFICIENCY
surface active substances
Surfactant phospholipids
therapeutics
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Zusammenfassung:Pulmonary alveolar proteinosis (PAP) is a rare disorder characterized by the accumulation of surfactant within the alveoli. Surfactant phospholipids and proteins are produced by type II alveolar epithelial cells, and subsequently cleared by the alveolar macrophages. Cell signaling initiated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor is essential to the breakdown of surfactant. The acquired form of PAP most commonly involves circulating anti-bodies to GM-CSF, with resultant accumulation of surfactant. American Thoracic Society , 13 May 2016, 18 May 2016,