Activation of Mitogen-Activated Protein Kinases and Cyclic AMP Response Element-Binding Protein in Synaptic Plasticity

Activation of Mitogen-Activated Protein Kinases and Cyclic AMP Response Element-Binding Protein in Synaptic Plasticity

Current evidence supports a critical role for cAMP in synaptic plasticity. Forskolin increases adenylyl cyclase activity to generate cAMP which induces a long-lasting potentiation of excitatory post synaptic potentials in the hippocampal dentate gyrus to 137 plus or equal to 5% of control, which per...

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Bibliographische Detailangaben
1. Verfasser: Voulalas,Pamela J
Format: Report
Sprache:eng
Schlagworte:
calcium
cells(biology)
kinases
Medicine and Medical Research
proteins
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Zusammenfassung:Current evidence supports a critical role for cAMP in synaptic plasticity. Forskolin increases adenylyl cyclase activity to generate cAMP which induces a long-lasting potentiation of excitatory post synaptic potentials in the hippocampal dentate gyrus to 137 plus or equal to 5% of control, which persists for at least 60 min after forskolin removal..