Trinitrobenzenesulfonic Acid Colitis Induces Changes in the Contractile Response of Circular Smooth Muscle in the Distal Colon

Diarrhea is a common symptom of colitis. Alterations in colonic muscle contractility, through both neural and smooth muscle mechanisms, contribute to the abnormal motility patterns associated with inflammatory bowel disease. Changing inflammatory milieu may cause stage-dependent alterations of the muscle contractile response. The aim was to study colonic circular smooth muscle response to acetylcholine and the tachykinins during acute and chronic inflammation.