Interference Among Group A Arboviruses

Interference Among Group A Arboviruses

Interference among group A arboviruses that did not involve the mediation of interferon is described. Interference was observed only if the interfering virus had an advantage over the challenge virus either in time or in multiplicity of infection. Adsorption, penetration, and uncoating of challenge...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Zebovitz, Eugene, Brown, Arthur
Format: Report
Sprache:eng
Schlagworte:
BIOSYNTHESIS
EQUINE ENCEPHALOMYELITIS VIRUS
GROUP A ARBOVIRUSES
GROWTH(PHYSIOLOGY)
INHIBITION
INTERFERENCE
Microbiology
MORPHOLOGY(BIOLOGY)
MUTATIONS
RIBONUCLEIC ACIDS
SENSITIVITY
TABLES(DATA)
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Beschreibung
Zusammenfassung:Interference among group A arboviruses that did not involve the mediation of interferon is described. Interference was observed only if the interfering virus had an advantage over the challenge virus either in time or in multiplicity of infection. Adsorption, penetration, and uncoating of challenge virus did not appear to be inhibited, but the synthesis of infectious viral RNA of the challenge virus was significantly retarded. With temperature-sensitive viruses or mutants, the replication of viral RNA by the interfering virus was required to establish interference. A mechanism of interference based on a competition for replication sites or substrates was compared with other possible explanations.