Secondary Evaluation of Potential Antimalarial Agents

Test systems were developed and used for screening a number of drugs against normal and drug-resistant blood-induced Plasmodium Berghei infections in mice and Plasmodium gallinaceum infections in chicks. A colony of Aedes aegypti was established to provide infective sporozoite for suppressive testin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	King,Maurice E, Schneider,Morris D, Shefner,Alan M
Format:	Report
Sprache:	eng
Schlagworte:	AEDES Aedes aegypti Aedes stephensi ANTIMALARIALS CHEMOTHERAPEUTIC AGENTS DRUGS INFECTIOUS DISEASES LABORATORY ANIMALS LIFE CYCLES PARASITIC DISEASES Pharmacology PLASMODIUM Plasmodium berghei Plasmodium gallinaceum
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Test systems were developed and used for screening a number of drugs against normal and drug-resistant blood-induced Plasmodium Berghei infections in mice and Plasmodium gallinaceum infections in chicks. A colony of Aedes aegypti was established to provide infective sporozoite for suppressive testing against Plasmodium gallinaceum; a colony of Aedes. stephensi was setup for prophylactic and therapeutic screening against Plasmodium berghei yoelli. The characteristics of plasmodia cryopreserved in liquid nitrogen were investigated. Techniques were developed whereby plasmodia could be stored for long periods without adverse effects on the viability, virulence or drug-resistant properties of malarial strains. (Author) See also report dated Apr 72,AD-743 208.