Effects of Methylene Chloride Exposure on the Spontaneous Activity of Mice

The experiments described were conducted during continuous exposure of mice to methylene chloride (dichloromethane). The group exposed to 5000 ppm methylene chloride was severely affected and by the seventh day 50% of the mice died. The 1000 ppm exposed group survived the entire four weeks and the spontaneous activity findings are presented. Results indicate that there is a definite trend toward lower activity during exposure, and when one compares the first two-week exposure period with the second two-week exposure period, activity seems to be stabilized at a considerably lower level. Presented at the Annual Conference on Environmental Toxicology (2nd), Fairborn, Ohio, 31 Aug, 1-2 Sep 71, sponsored by the SysteMed Corp., Dayton, Ohio. See also AD-751 434 and AD-751 436.