Automated Dithionite Test for the Rapid, Inexpensive Detection of Hemoglobin S and Non-S Sickling Hemoglobinopathies

Automated Dithionite Test for the Rapid, Inexpensive Detection of Hemoglobin S and Non-S Sickling Hemoglobinopathies

The adaptation to an automated version of the dithionite tube test and the urea-dithionite tube test as discussed in USAMRL Report No. 942 is presented. The automated dithionite test makes it possible to screen 120 hemoglobin specimens per hour at a reagent cost of approximately 2 cents to 4 cents e...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Nalbandian,Robert M, Nichols,Bruce M, Camp,Frank R , Jr, Lusher,Jeanne M, Conte,Nicholas F
Format: Report
Sprache:eng
Schlagworte:
ANEMIAS
AUTOMATION
BLOOD DISEASES
DETECTION
DIAGNOSIS(GENERAL)
DITHIONITE TEST
EFFICIENCY
HEMOGLOBIN
HEMOGLOBIN S
Medicine and Medical Research
SICKLE CELL ANEMIA
SULFUR COMPOUNDS
TEST METHODS
UREA
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Beschreibung
Zusammenfassung:The adaptation to an automated version of the dithionite tube test and the urea-dithionite tube test as discussed in USAMRL Report No. 942 is presented. The automated dithionite test makes it possible to screen 120 hemoglobin specimens per hour at a reagent cost of approximately 2 cents to 4 cents each. Increased specificity of the results may be obtained but at the expense of half the rate of the automated dithionite test. Thus, about 60 determinations per hour can be performed at about 4 cents to 8 cents per set. Both automated methods have proven to be highly reliable in extended field trials in military and civilian populations. (Author) See also AD-732 356.