GROWTH OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS IN HUMAN DIPLOID CELL STRAIN WI-38

GROWTH OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS IN HUMAN DIPLOID CELL STRAIN WI-38

It was demonstrated that Venezuelan equine encephalomyelitis (VEE) virus replicated in and adapted rapidly to human diploid cell strain WI-38. Peak titers of approximately 10 to the 9.8th power mouse intracerebral 50% lethal doses were obtained at low passage levels in Eagles basal medium supplement...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Reitman, Morton, Green, Leonard
Format: Report
Sprache:eng
Schlagworte:
ARBOVIRUSES
CULTURE MEDIA
GROWTH(PHYSIOLOGY)
Microbiology
TISSUE CULTURE CELLS
VACCINES
VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS
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Zusammenfassung:It was demonstrated that Venezuelan equine encephalomyelitis (VEE) virus replicated in and adapted rapidly to human diploid cell strain WI-38. Peak titers of approximately 10 to the 9.8th power mouse intracerebral 50% lethal doses were obtained at low passage levels in Eagles basal medium supplemented with calf serum. VEE virus replicated poorly in serum-free medium. Propagation of VEE virus was accompanied by the production of hemagglutinin and cytopathogenic effects. Availability: Pub. in Applied Microbiology, v19 n1 p196-198 Jan 1970.