TRANSPLANTATION ANTIGENS IN KERATOPLASTY. I. ISOLATION OF A SOLUBLE FRACTION WITH TRANSPLANTATION ANTIGEN ACTIVITY

TRANSPLANTATION ANTIGENS IN KERATOPLASTY. I. ISOLATION OF A SOLUBLE FRACTION WITH TRANSPLANTATION ANTIGEN ACTIVITY

A soluble protein fraction has been isolated from the cornea by simple aqueous extraction. This preparation possesses transplantation antigen activity as demonstrated by its ability to induce a specific sensitization resulting in the accelerated destruction of a corneal graft. The corneal antigen pr...

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Bibliographische Detailangaben
Hauptverfasser: Leibowitz,Howard M, Luzzio,Anthony J
Format: Report
Sprache:eng
Schlagworte:
Anatomy and Physiology
ANTIGEN ANTIBODY REACTIONS
ANTIGENS + ANTIBODIES
CORNEA
EYE
IMMUNITY
Medicine and Medical Research
RESPONSE(BIOLOGY)
SENSITIVITY
SURGICAL TECHNIQUES
TRANSPLANTATION
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Zusammenfassung:A soluble protein fraction has been isolated from the cornea by simple aqueous extraction. This preparation possesses transplantation antigen activity as demonstrated by its ability to induce a specific sensitization resulting in the accelerated destruction of a corneal graft. The corneal antigen preparation is also capable of stimulating the production of humoral antibodies but the relationship between the transplantation immunity and the antibody response remains to be elaborated. (Author)