SELECTION OF RADIATION-RESISTANT ANIMALS

Rodents were exposed at weekly intervals to an ethanol-saturated air ambient. Body weight was monitored before and after each exposure. Sedation and recovery times were observed. After a rest period of several days the animals were irradiated to a dose level at which a 100% mortality was expected. T...

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Hauptverfasser:	Peters,Ignatius G, Hamilton,Horace E, Melville,George S , Jr, Ballinger,Edwin R
Format:	Report
Sprache:	eng
Schlagworte:	Anatomy and Physiology BODY WEIGHT ETHANOLS EXPOSURE(PHYSIOLOGY) HAMSTERS MICE MORTALITY RATE RADIATION DOSAGE RADIATION EFFECTS RADIATION TOLERANCE Radiobiology RATS RODENTS SELECTION SENSITIVITY STRESS(PHYSIOLOGY) SURVIVAL(PERSONNEL)
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Zusammenfassung:	Rodents were exposed at weekly intervals to an ethanol-saturated air ambient. Body weight was monitored before and after each exposure. Sedation and recovery times were observed. After a rest period of several days the animals were irradiated to a dose level at which a 100% mortality was expected. The postirradiation survival of the rodents was correlated (P .05- .01) in preliminary experiments with preirradiation ethanol-induced body weight changes. The weight change-survival relationship was observed in five different species of rodents. The correlation was found to be present for periods of time up to twenty-one days following stress testing. The test may be applicable to animals exposed to a dose range of several hundred roentgens at the dose level producing a high percentage of mortality. No detectable modification of the postirradiation survival time of the stressed animals was observed. Plots of radiation-induced mortality times were made for the five rodent species. (Author)