MORPHOLOGY OF IMMUNOGENESIS DURING EXPERIMENTAL ANTHRAX VACCINATION

During a histological study of the internal organs of experimental animals, vaccinated with the STI-1 and 34-F2 strains, changes which are characteristic for anthrax were not revealed. Insignificant changes, detected in the liver, heart and kidneys of vaccinated animals, represented a reaction to the introduction of the antigen. When rabbits and guinea pigs received the STI-1 and 34-F2 vaccine strains, changes developed at the site of injection, the lymph nodes, spleen, bone marrow and lungs. These changes made it possible to judge the nature of the vaccinal process and its intensity. During the macro- and microscopic investigation of tissue from the sites where the STI-1 and 34-F2 vaccine strains were administered, it was established that the latter caused a significantly stronger local reaction, being expressed in an intensive leukocytic infiltration up to the formation of abscesses and necrosis of the muscle fibers of the subcutaneous tissue. Following the vaccinations with both strains, the process of immunogenesis began with the 1st day (at the site of administration) and was preserved over a period of 5 months. Trans. of Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii (USSR) v43 n12 p58-63 1966, by Charles T. Ostertag, Jr.