EFFECT OF HYPOXIA ON MYOCARDIUM IN HEART-LUNG PREPARATION

EFFECT OF HYPOXIA ON MYOCARDIUM IN HEART-LUNG PREPARATION

Starling heart-lung preparations were ventilated with various mixtures of oxygen, nitrogen, and carbon dioxide, and the performance of the heart was evaluated by relating stroke work to left atrial pressure. At oxygen tensions of arterial blood between 65 mm Hg and 25 mm Hg performance improved. At...

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Bibliographische Detailangaben
Hauptverfasser: Nelad,N. S, Ogden,Eric
Format: Report
Sprache:eng
Schlagworte:
Anatomy and Physiology
BLOOD CIRCULATION
BLOOD PRESSURE
CARBOHYDRATES
CARBON DIOXIDE
CARDIOVASCULAR SYSTEM
HEART
HYPOXIA
IN VITRO ANALYSIS
LACTATES
METABOLISM
NITROGEN
OXYGEN
PRESSURE
PYRUVATES
RESPONSE(BIOLOGY)
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Zusammenfassung:Starling heart-lung preparations were ventilated with various mixtures of oxygen, nitrogen, and carbon dioxide, and the performance of the heart was evaluated by relating stroke work to left atrial pressure. At oxygen tensions of arterial blood between 65 mm Hg and 25 mm Hg performance improved. At 20 mm Hg or lower the performance was impaired but the impairment was reversible. The impairment was accompanied by an accumulation of lactate and pyruvate in the blood which also was reversible as oxygen tension was restored. Possible mechanism of these changes is discussed. (Author)