IMMUNOLOGICAL ACTIVITY OF LYMPHOID ORGANS DURING AEROSOL AND SUBCUTANIOUS TYPHOID IMMUNIZATION

The single aerosol and subcutaneous immunization of rabbits with typhoid whole antigen caused an intensive plasmocytic reaction, expressed in a considerable increase in the number of young plasmatic cells both in the regional and distant lymph nodes. In the rabbits, both during the aerosol and subcutaneous immunization, the number of RNA enriched lymphocytes increased in the peripheral blood. The increase of the titer of typhoid agglutinins in the regional lymph nodes in rabbits vaccinated by the aerosol and subcutaneous methods began with the 3rd day following immunization and reached the maximum by the 10th day. In the first days following immunization the titers of agglutinins in the blood serum were somewhat lower than in the homogenates of the regional lymph nodes; however they became considerably higher in later periods. The double aerosol immunization caused an active plasmocytic reaction in the regional and distant lymph nodes which set in earlier than following the single immunization. In the investigations conducted an expressed correlation was detected in the level of plasmocytic reaction, accumulation of RNA in the lymphocytes of the peripheral blood and the serological shifts in rabbits, subjected to subcutaneous and aerosol immunization with typhoid vaccine. Trans. of Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii (USSR) v41 n11 p128-33 1964.