IMPROVEMENT OF THE NUTRIENT MEDIUM AND THE SEARCH FOR A METHOD OF PURIFYING THE PROTECTIVE ANTHRAX ANTIGEN

IMPROVEMENT OF THE NUTRIENT MEDIUM AND THE SEARCH FOR A METHOD OF PURIFYING THE PROTECTIVE ANTHRAX ANTIGEN

As a result of work on cultivation of anthrax microbe to obtain a protective antigen a milk-peptone medium was suggested. To isolate the anthrax antigen from the culture fluid a method of its precipitation with ethyl alcohol is recommended, with subsequent concentration and stabilization of the anti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Aleksandrov, N I, Gefen, N E, Runova, V F, Budak, A P, Yezepchuk, Yu V, Lebedinskiy, V A, Filippenko, A I
Format: Report
Sprache:eng
Schlagworte:
ADSORPTION
ANTIBODIES
ANTIGENS
BACILLUS ANTHRACIS
CULTURE MEDIA
FOREIGN REPORTS
IMMUNITY
Microbiology
Pharmacology
PURIFICATION
RUSSIAN LANGUAGE
TOXICITY
TRANSLATIONS
USSR
VACCINES
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Beschreibung
Zusammenfassung:As a result of work on cultivation of anthrax microbe to obtain a protective antigen a milk-peptone medium was suggested. To isolate the anthrax antigen from the culture fluid a method of its precipitation with ethyl alcohol is recommended, with subsequent concentration and stabilization of the antigen, its sorption on aluminum hydroxide and lyophilization. Chemical sorbed vaccine, obtained by the mentioned method, provoked but insignificant postvaccinal reactions, and possessed sufficiently high immunogenic properties. Trans. of Zhurnal Mikrobiologii, Epidemiologii i immunobiologii (USSR), v40, p103-7, Jan 1963.