EFFECT OF THE CONTAINER ON THE STABILITY OF AQUEOUS SOLUTIONS OF PRALIDOXIME CHLORIDE

The storage stability of solutions of pralidoxime chloride (2-PAMCl) in metal containers was studied. The metal containers were a component part of the AtroPen Auto-Injector. The oxime was placed in various containers, and its rate of decomposition was observed at ambient temperatures, 40, 65, and 9...

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Bibliographische Detailangaben
Hauptverfasser:	May, Jon R, Kondritzer, Albert A
Format:	Report
Sprache:	eng
Schlagworte:	ATROPINE CATALYSIS CHEMICAL WARFARE THERAPEUTIC AGENTS CHEMOTHERAPY CHLORIDES COMPLEX COMPOUNDS CONTAINERS GLASS INJECTIONS(MEDICINE) NERVE AGENTS Organic Chemistry OXIMES Pharmacology PLASTICS PYRIDINE ALDOXIME METHOCHLORIDE STABILITY STAINLESS STEEL STEEL 1050 STORAGE
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Zusammenfassung:	The storage stability of solutions of pralidoxime chloride (2-PAMCl) in metal containers was studied. The metal containers were a component part of the AtroPen Auto-Injector. The oxime was placed in various containers, and its rate of decomposition was observed at ambient temperatures, 40, 65, and 95 C. Results are presented graphically. Decreased stability may be used to catalysis by the metallic surface. It the AtroPen Auto-Injector is to be used for the administration of 2-PAMCl solutions, glass or suitable plastic containers should be used. (Author)