CHLOROTHIAZIDE ATTENUATION OF THE PRESSOR RESPONSES TO EPINEPHRINE, LEVARTERENOL, AND ANGIOTENSIN IN THE PERFUSED RENAL VASCULAR BED

CHLOROTHIAZIDE ATTENUATION OF THE PRESSOR RESPONSES TO EPINEPHRINE, LEVARTERENOL, AND ANGIOTENSIN IN THE PERFUSED RENAL VASCULAR BED

A study was made to investigate the effect of acute local chlorothiazide administration on renal vascular resistance and to ascertain if chlorothiazide alters the pressor response to vasoactive agents. Chlorothiazide did not ACUTELY ALTER RENAL VASCULAR RESISTANCE. The pressor responses to epinephri...

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Bibliographische Detailangaben
Hauptverfasser: GILLENWATER, JAY Y, SCOTT, JERRY B, FROHLICH, EDWARD D
Format: Report
Sprache:eng
Schlagworte:
ANGIOTENSIN
CARDIOVASCULAR AGENTS
LABORATORIES
NOREPINEPHRINE
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Zusammenfassung:A study was made to investigate the effect of acute local chlorothiazide administration on renal vascular resistance and to ascertain if chlorothiazide alters the pressor response to vasoactive agents. Chlorothiazide did not ACUTELY ALTER RENAL VASCULAR RESISTANCE. The pressor responses to epinephrine, levarterenol, and angiotensin were attenuated and the depressor response to magnesium chloride (MgCl2) was potentiated. Acute local administration of chlorothiazide in the perfused renal vascular bed of the dog acutely alters the pressor response to certain vasoactive agents. (Author)