Sasa veitchii extract protects against carbon tetrachloride-induced hepatic fibrosis in mice

The current study aimed to investigate the hepatoprotective effects of Sasa veitchii extract (SE) on carbon tetrachloride (CCl )-induced liver fibrosis in mice. Male C57BL/6J mice were intraperitoneally injected with CCl dissolved in olive oil (1 g/kg) twice per week for 8 weeks. SE (0.1 mL) was adm...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Environmental health and preventive medicine 2018-10, Vol.23 (1), p.49-10, Article 49
Hauptverfasser: Yoshioka, Hiroki, Nonogaki, Tsunemasa, Fukaya, Shiori, Ichimaru, Yoshimi, Nagatsu, Akito, Yoshikawa, Masae, Fujii, Hirohisa, Nakao, Makoto
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The current study aimed to investigate the hepatoprotective effects of Sasa veitchii extract (SE) on carbon tetrachloride (CCl )-induced liver fibrosis in mice. Male C57BL/6J mice were intraperitoneally injected with CCl dissolved in olive oil (1 g/kg) twice per week for 8 weeks. SE (0.1 mL) was administered orally once per day throughout the study, and body weight was measured weekly. Seventy-two hours after the final CCl injection, mice were euthanized and plasma samples were collected. The liver and kidneys were collected and weighed. CCl administration increased liver weight, decreased body weight, elevated plasma alanine aminotransferase, and aspartate aminotransferase and increased liver oxidative stress (malondialdehyde and glutathione). These increases were attenuated by SE treatment. Overexpression of tumor necrosis factor-α was also reversed following SE treatment. Furthermore, CCl -induced increases in α-smooth muscle actin, a marker for hepatic fibrosis, were attenuated in mice treated with SE. Moreover, SE inhibited CCl -induced nuclear translocation of hepatic nuclear factor kappa B (NF-κB) p65 and phosphorylation of mitogen-activated protein kinase (MAPK). These results suggested that SE prevented CCl -induced hepatic fibrosis by inhibiting the MAPK and NF-κB signaling pathways.
ISSN:1342-078X
1347-4715
DOI:10.1186/s12199-018-0739-7