Screening of irregular antibodies in pregnancy of different gestational weeks in Shanghai: cliniacal significance and safety strategy

Objective: To analyze the results of irregular antibody detection in early and late pregnancy and to study its clinical significance and safety strategy. Methods: A total of 14 770 pregnant women visited Shanghai First Maternity and Infant Hospital from July 2018 to September 2019 were enrolled and detected for irregular antibodies in the first trimester (≤16 weeks) and late pregnancy (≥32 weeks). In pregnant women with positive irregular antibody, umbilical cord blood or venous blood of newborn infant were collected for the testing of hemolytic disease of fetus and newborn HDFN. Results: Of the 14 770 case of pregnant women, 63 cases had irregular antibodies detected in the early pregnancy, with a positive rate of 0.43%, while 97 cases had irregular antibodies detected in late pregnancy, with a positive rate of 0.66%( χ2=7.264, P< 0.05). The number of cases with irregular antibody detected increased by 34cases in late pregnancy, accounting for 35.05% of the total positive irregular antibody cases. Majority o