P1.10: Beneficial Effect of Sequential Nephron Blockade of Central Pressure and Large Artery Remodelling in Resistant Hypertension

Objective We have previously shown that combined renin-angiotensin system blockade (RB) was less effective than sequential-nephron blockade (SNB) for controlling BP in resistant hypertension (RH). Whether this is accompanied with an improvement in the mechanical properties of large arteries is unkno...

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Veröffentlicht in:Artery research 2013, Vol.7 (3-4), p.113-113
Hauptverfasser: Beaussier, H. B., Briet, M. B., Michael, F. M., Bobrie, G. B., Peyrard, S. P., Plouin, P. F. P., Laurent, S. L., Azizi, M. A., Boutouyrie, P. B.
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Sprache:eng
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Zusammenfassung:Objective We have previously shown that combined renin-angiotensin system blockade (RB) was less effective than sequential-nephron blockade (SNB) for controlling BP in resistant hypertension (RH). Whether this is accompanied with an improvement in the mechanical properties of large arteries is unknown. Design and method Pts with daytime ambulatory SBP/DBP (dASBP/dADBP) >135 and/or 85 mmHg, despite 4 week with irbesartan (Irb)+HCTZ+amlodipine, were randomised to SNB (n=82) or RB (n=82) for 12 weeks. Central pulse pressure (CPP) and carotid-femoral pulse wave velocity (PWV) were measured by aplanation tonometry. High-resolution echotracking system (Walltrack ® ) was used to measure carotid artery diameter (Dcca), wall thickness (WT), circumferential wall stress (CWS), and stiffness. All parameters were measured at baseline and week 12. Results Baseline clinical characteristics did not differ between groups. dASBP decreased more in SNB (−19±12 mmHg) vs RB (−8±13 mmHg, p
ISSN:1872-9312
1876-4401
1876-4401
DOI:10.1016/j.artres.2013.10.041