Hypolipidemic effects of hydroalcoholic extract from walnut male flowers on diabetic rats

Abstract Background & aim: Diabetes is a metabolic disorder resulting from defects in insulin secretion and function. In the current study we checked the Hypolipidemic effects of the walnut male flowers on the diabetic rats. Methods: 72 adult male Wistar rats (220-250g) were randomly selected and divided into three groups control group (n=8) without any intervention, induced diabetic group (n=32), 8 receiving normal saline and 24 receiving 3 different doses of extract (2, 4 and 6 g/kg), induced diabetic group (n=32) without treatment with extract. Diabetes was induced in rats by intraperitoneal injection of 60 mg/kg of streptozotocin. In the experimental groups, rats were treated for 15 days with a single dose of the extract for each day. At the first and end of the 15th day, a blood sample was taken from the experimental and control groups and the serum levels of glucose, TG, Cholesterol, and HDL-cholesterol were measured. Results: Our results showed that the hydro-alcoholic extract of walnut male flowers will decrease the levels of glucose , TG, Cholesterol, and LDL-cholesterol and increase the levels of HDL and HDL/LDL ratio in treated diabetic groups (P