Relapse of Tropheryma whipplei endocarditis treated by trimethoprim/sulfamethoxazole, cured by hydroxychloroquine plus doxycycline

Highlights • Thrimethoprim/sulfamethoxazol failed to cure T. whipplei endocarditis • The best choice of treatment for T. whipplei infections is controversial • The combination of doxycycline and hydroxychloroquine is the most effective treatment • Treatment guidelines for T. whipplei infections shou...

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Veröffentlicht in:	International journal of infectious diseases 2015-01, Vol.30 (C), p.17-19
Hauptverfasser:	Emonet, Stephane, Wuillemin, Timothee, Harbarth, Stephan, Wassilew, Nasstasja, Cikirikcioglu, Mustafa, Schrenzel, Jacques, Lagier, Jean-Christophe, Raoult, Didier, van Delden, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - therapeutic use Aortic Valve - microbiology Ceftriaxone - therapeutic use Doxycycline Doxycycline - therapeutic use Drug Therapy, Combination Endocarditis Endocarditis, Bacterial - diagnosis Endocarditis, Bacterial - drug therapy Guidelines Heart Valve Diseases - diagnosis Heart Valve Diseases - drug therapy Humans Hydroxychloroquine Hydroxychloroquine - therapeutic use Infectious Disease Male Middle Aged Pulmonary/Respiratory Recurrence Trimethoprim, Sulfamethoxazole Drug Combination - therapeutic use Trimethoprim/sulfamethoxazole Tropheryma - isolation & purification Whipple Disease - diagnosis Whipple Disease - drug therapy Whipple's disease
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Zusammenfassung:	Highlights • Thrimethoprim/sulfamethoxazol failed to cure T. whipplei endocarditis • The best choice of treatment for T. whipplei infections is controversial • The combination of doxycycline and hydroxychloroquine is the most effective treatment • Treatment guidelines for T. whipplei infections should be revisited
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2014.11.003