Smoking affects gene expression in blood of patients with ischemic stroke

Objective Though cigarette smoking (CS) is a well‐known risk factor for ischemic stroke (IS), there is no data on how CS affects the blood transcriptome in IS patients. Methods We recruited IS‐current smokers (IS‐SM), IS‐never smokers (IS‐NSM), control‐smokers (C‐SM), and control‐never smokers (C‐NS...

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Veröffentlicht in:	Annals of clinical and translational neurology 2019-09, Vol.6 (9), p.1748-1756
Hauptverfasser:	Cheng, Xiyuan, Ferino, Eva, Hull, Heather, Jickling, Glen C., Ander, Bradley P., Stamova, Boryana, Sharp, Frank R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Atherosclerosis Blood platelets Blood Platelets - metabolism Brain Ischemia - blood Brain Ischemia - genetics Cigarette Smoking - blood Cigarette Smoking - genetics Consent Diabetes Female Funding Gender Gene Expression Genomics Humans Hypertension Leukocytes - metabolism Male Middle Aged NMR Nuclear magnetic resonance RNA polymerase Smoking cessation Software Stroke Stroke - blood Stroke - genetics Studies Transcriptome
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Zusammenfassung:	Objective Though cigarette smoking (CS) is a well‐known risk factor for ischemic stroke (IS), there is no data on how CS affects the blood transcriptome in IS patients. Methods We recruited IS‐current smokers (IS‐SM), IS‐never smokers (IS‐NSM), control‐smokers (C‐SM), and control‐never smokers (C‐NSM). mRNA expression was assessed on HTA‐2.0 microarrays and unique as well as commonly expressed genes identified for IS‐SM versus IS‐NSM and C‐SM versus C‐NSM. Results One hundred and fifty‐eight genes were differentially expressed in IS‐SM versus IS‐NSM; 100 genes were differentially expressed in C‐SM versus C‐NSM; and 10 genes were common to both IS‐SM and C‐SM (P
ISSN:	2328-9503 2328-9503
DOI:	10.1002/acn3.50876