Can polydatin have a beneficial role against bisphenol an exposure in rats?

The present study was conducted to evaluate the effects of chronic bisphenol A (BPA) exposure and the possible protective effects of polydatin (PD) on different organs, oxidant-antioxidant status and spermatological parameters in male Wistar rats. Male Wistar rats (2 to 3 months old) were randomly divided into 5 groups (n = 6). Group 1 was the control (daily 0.5ml distilled water). Groups 2, 3, 4 and 5 daily received 0.5 ml olive oil (OO), 25 mg/kg bisphenol A in 0.5 olive oil (BPA), 150 mg/kg polydatin (PD), and a mixture of 25 mg/kg bisphenol A in 0.5 olive oil + 150 mg/kg polydatin (BPA-PD), respectively, daily for 45 days. BPA had negative effects on percent abnormal sperm and Hypo-osmotic swelling-Eosin (HE) test (P