Effect-enhancing and toxicity-reducing effects of Chaihu Jia Longgu Muli decoction in the treatment of multimorbidity with depression: a systematic review and meta-analysis

Chaihu Jia Longgu Muli Decoction (CLMD) is a traditional Chinese medicine for treating depression. This study investigated the effect of CLMD combined with antidepressants on multimorbidity with depression (MMD). Published randomized controlled trials were collected from PubMed, Web of Science, Chinese National Knowledge Infrastructure, China Science and Technology Journal, Wanfang and China Biomedical Literature Service System Databases. Participants were divided into study groups (CLMD combined with antidepressants) and control groups (antidepressants). RevMan5.4 software was used for data analysis. Hamilton's Depression Scale score was significantly lower (MD = −5.62, 95%CI [−5.86, −5.37], p