Transcriptome Analysis Showed a Differential Signature between Invasive and Non-invasive Corticotrophinomas

Transcriptome Analysis Showed a Differential Signature between Invasive and Non-invasive Corticotrophinomas

ACTH-dependent hypercortisolism caused by a pituitary adenoma [Cushing's disease (CD)] is the most common cause of endogenous Cushing's syndrome. CD is often associated with several morbidities, including hypertension, diabetes, osteoporosis/bone fractures, secondary infections, and increa...

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Veröffentlicht in:Frontiers in endocrinology (Lausanne) 2017-03, Vol.8, p.55-55
Hauptverfasser: de Araújo, Leonardo Jose Tadeu, Lerario, Antonio Marcondes, de Castro, Margaret, Martins, Clarissa Silva, Bronstein, Marcello Delano, Machado, Marcio Carlos, Trarbach, Ericka Barbosa, Villares Fragoso, Maria Candida Barisson
Format: Artikel
Sprache:eng
Schlagworte:
anterior pituitary
Cushing’s disease
Endocrinology
gene expression
microarray
neuroendocrine tumors
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Zusammenfassung:ACTH-dependent hypercortisolism caused by a pituitary adenoma [Cushing's disease (CD)] is the most common cause of endogenous Cushing's syndrome. CD is often associated with several morbidities, including hypertension, diabetes, osteoporosis/bone fractures, secondary infections, and increased cardiovascular mortality. While the majority (≈80%) of the corticotrophinomas visible on pituitary magnetic resonance imaging are microadenomas (MICs,
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2017.00055