One-step Selective Synthesis of 13-epi-manoyl Oxide

One-step Selective Synthesis of 13-epi-manoyl Oxide

The selective one-step synthesis of 13-epi-manoyl oxide is reported based on a low-temperature superacidic cyclization of sclareol. The reaction conditions have been finely tuned in order to achieve a 9:1 ratio between epimeric oxides in favor of the desired 13-epi-oxide.

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Veröffentlicht in:Chemistry journal of Moldova 2021-07, Vol.16 (1), p.99-104
Hauptverfasser: Morarescu, Olga, Traistari, Marionela, Barba, Alic, Duca, Gheorghe, Ungur, Nicon, Kulcițki, Veaceslav
Format: Artikel
Sprache:eng
Schlagworte:
cyclization
ether
labdane
sclareol
superacid
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Beschreibung
Zusammenfassung:The selective one-step synthesis of 13-epi-manoyl oxide is reported based on a low-temperature superacidic cyclization of sclareol. The reaction conditions have been finely tuned in order to achieve a 9:1 ratio between epimeric oxides in favor of the desired 13-epi-oxide.
ISSN:1857-1727
2345-1688
DOI:10.19261/cjm.2021.820