Antimicrobial Potential of Streptomyces ansochromogenes (PB 3 ) Isolated From a Plant Native to the Amazon Against Pseudomonas aeruginosa

The objective of this study was to evaluate the antibacterial action of filamentous bacteria isolated from the leaf. An endophytic bacterium has been identified by classical and molecular techniques as . Screening for antibacterial action against pathogens with medical relevance ( ATCC 700603, ATCC 15692, ATCC 6538, ATCC 27012, , ATCC 24065, and ATCC 24067) demonstrated activity against the bacterium ATCC 0030 with inhibition diameter zones (IDZ) of 17.6 ± 0.25 mm in the preliminary screening in solid medium. After fermentation in liquid medium, an IDZ of 19.6 ± 0.46 mm and a minimum inhibitory concentration (MIC) of 0.5 mg/mL were detected. The antibiofilm action was observed with 100% inhibition of biofilm formation at a concentration of 0.250 mg/mL. When the infection curve was prepared, it was observed that the metabolite was effective in protecting the larvae of . The metabolite does not show toxicity for eukaryotic cells. The leishmanicidal activity demonstrated that the metabolite presented a dose-dependent effect on the promastigotes forms of growth and the estimated IC /72 h was 71.65 ± 7.4 μg/mL. Therefore, it can be concluded that the metabolite produced by the endophytic bacterium sp. is promising for future use as an alternative strategy against bacterial resistance.