Integrated GWAS and mRNA Microarray Analysis Identified IFNG and CD40L as the Central Upstream Regulators in Primary Biliary Cholangitis

Integrated GWAS and mRNA Microarray Analysis Identified IFNG and CD40L as the Central Upstream Regulators in Primary Biliary Cholangitis

Genome‐wide association studies (GWASs) in European and East Asian populations have identified more than 40 disease‐susceptibility genes in primary biliary cholangitis (PBC). The aim of this study is to computationally identify disease pathways, upstream regulators, and therapeutic targets in PBC th...

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Veröffentlicht in:Hepatology communications 2020-05, Vol.4 (5), p.724-738
Hauptverfasser: Ueno, Kazuko, Aiba, Yoshihiro, Hitomi, Yuki, Shimoda, Shinji, Nakamura, Hitomi, Gervais, Olivier, Kawai, Yosuke, Kawashima, Minae, Nishida, Nao, Kohn, Seik‐Soon, Kojima, Kaname, Katsushima, Shinji, Naganuma, Atsushi, Sugi, Kazuhiro, Komatsu, Tatsuji, Mannami, Tomohiko, Matsushita, Kouki, Yoshizawa, Kaname, Makita, Fujio, Nikami, Toshiki, Nishimura, Hideo, Kouno, Hiroshi, Kouno, Hirotaka, Ohta, Hajime, Komura, Takuya, Tsuruta, Satoru, Yamauchi, Kazuhiko, Kobata, Tatsuro, Kitasato, Amane, Kuroki, Tamotsu, Abiru, Seigo, Nagaoka, Shinya, Komori, Atsumasa, Yatsuhashi, Hiroshi, Migita, Kiyoshi, Ohira, Hiromasa, Tanaka, Atsushi, Takikawa, Hajime, Nagasaki, Masao, Tokunaga, Katsushi, Nakamura, Minoru
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Antigens
Biopsy
Cholangitis
Cytokines
Datasets
Females
Gene expression
Genomes
Genotype & phenotype
Ligands
Liver diseases
Metastasis
Original
Pathogenesis
Polymorphism
Principal components analysis
Quality control
Tumor necrosis factor-TNF
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Zusammenfassung:Genome‐wide association studies (GWASs) in European and East Asian populations have identified more than 40 disease‐susceptibility genes in primary biliary cholangitis (PBC). The aim of this study is to computationally identify disease pathways, upstream regulators, and therapeutic targets in PBC through integrated GWAS and messenger RNA (mRNA) microarray analysis. Disease pathways and upstream regulators were analyzed with ingenuity pathway analysis in data set 1 for GWASs (1,920 patients with PBC and 1,770 controls), which included 261 annotated genes derived from 6,760 single‐nucleotide polymorphisms (P 2 versus controls (P 
ISSN:2471-254X
2471-254X
DOI:10.1002/hep4.1497