Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma

Thyroid-Associated Ophthalmopathy after Radioactive Iodine Therapy for Metastatic Follicular Thyroid Carcinoma

Thyroid-associated ophthalmopathy (TAO) is an inflammation of the extraocular muscles and periorbital connective tissue caused by autoantibodies against common antigens to both the thyroid and orbit. The release of antigens and induction of hypothyroidism caused by radioactive iodine (RAI) therapy m...

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Veröffentlicht in:Case reports in endocrinology 2021-06, Vol.2021, p.1-4
Hauptverfasser: Murayama, Daisuke, Toda, Soji, Okubo, Yoichiro, Hayashi, Hiroyuki, Matsui, Ai, Yasukawa, Mio, Iwasaki, Hiroyuki
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Autoantibodies
Autoimmunity
Cancer
Cancer therapies
Carcinoma
Care and treatment
Case Report
Case reports
Denosumab
Endocrinology
Growth factors
Hypothyroidism
Iodine
Metabolism
Metastasis
Patients
Radiation
Radiotherapy
Thyroid cancer
Thyroid hormones
Thyrotropin
Vascular endothelial growth factor
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Zusammenfassung:Thyroid-associated ophthalmopathy (TAO) is an inflammation of the extraocular muscles and periorbital connective tissue caused by autoantibodies against common antigens to both the thyroid and orbit. The release of antigens and induction of hypothyroidism caused by radioactive iodine (RAI) therapy may exacerbate TAO. Here, we present the case of a 67-year-old-woman treated with RAI therapy for metastatic follicular thyroid carcinoma who presented with TAO during the course of sorafenib administration. Tg and TgAb levels were gradually decreased with sorafenib and lenvatinib treatment, and TAO was improved without any ophthalmologic treatment.
ISSN:2090-6501
2090-651X
DOI:10.1155/2021/3024639