Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses sup>† /sup

Design and Synthesis of a Novel Ganglioside Ligand for Influenza A Viruses sup>† /sup

A novel ganglioside bearing Neua2-3Gal and Neua2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the no...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2012-08, Vol.17 (8), p.9590-9620
Hauptverfasser: Tomohiro Nohara, Akihiro Imamura, Maho Yamaguchi, Kazuya I. P. J. Hidari, Takashi Suzuki, Tatsuya Komori, Hiromune Ando, Hideharu Ishida, Makoto Kiso
Format: Artikel
Sprache:eng
Schlagworte:
ganglioside
glycosylation
influenza virus
sialic acid
total synthesis
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Zusammenfassung:A novel ganglioside bearing Neua2-3Gal and Neua2-6Gal structures as distal sequences was designed as a ligand for influenza A viruses. The efficient synthesis of the designed ganglioside was accomplished by employing the cassette coupling approach as a key reaction, which was executed between the non-reducing end of the oligosaccharide and the cyclic glucosylceramide moiety. Examination of its binding activity to influenza A viruses revealed that the new ligand is recognized by Neua2-3 and 2-6 type viruses.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules17089590