动脉粥样硬化性疾病的DNA甲基化改变 DNA Methylation Changes in Atherosclerotic Diseases

动脉粥样硬化是缺血性卒中、冠心病等心脑血管疾病的主要病因。既往研究发现DNA甲基化在动脉粥样硬化斑块的发生、进展中具有重要调节作用，并在病变的不同阶段表现出细胞特异性改变。本文综述了动脉粥样硬化斑块中内皮细胞、平滑肌细胞、巨噬细胞以及动脉粥样硬化性疾病患者外周血免疫细胞中DNA甲基化模式改变相关研究，总结了动脉粥样硬化性卒中患者的DNA甲基化改变，以期为新靶点的发现和疾病诊治提供新的思路。 Abstract: Atherosclerosis is a major cause of cardiovascular diseases (CVD) such as ischemic stroke and coronary artery disease. Previous studies have found that DNA methylation plays a crucial regulatory role in the occurrence and progression of atherosclerotic plaques, with a cell-specific pattern in different stages of the progression. This article reviewed the DNA methylation changes in endothelial cells, smooth muscle cells, macrophages in atherosclerotic plaques and peripheral blood immune cells in patients with atherosclerotic disease, and summarized DNA methylation changes in patients with atherosclerotic stroke, to provide new ideas for clinical prevention and treatment of CVD and exploring new targets.