Non-invasive detection of pancreatic cancer by measuring DNA methylation of Basonuclin 1 and Septin 9 in plasma

Furthermore, CA 19-9 is often found to be elevated in benign conditions or in other cancers, making its utility limited. [...]it is important to identify new diagnostic biomarkers to improve PC detection. [...]present results may still be preliminary results because of relatively small sample sizes. [...]large scale and prospective studies should be performed to confirm our findings. [...]the present study indicates that DNA methylation levels of BNC1 and SEPT9 are elevated in PC tissues and in plasma-derived cell-free DNA from patients with PC.