Plasma and cerebrospinal fluid neurofilament light concentrations reflect neuronal damage in systemic lupus Erythematosus

Neuronal damage in systemic lupus erythematosus (SLE) is common, but the extent and mechanisms are unclear. Neurofilament light (NfL) concentrations rise in plasma and cerebrospinal fluid (CSF) during neuronal damage in various neurological disorders. In this cross-sectional study, plasma and CSF co...

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Veröffentlicht in:	BMC neurology 2022-12, Vol.22 (1), p.467-467, Article 467
Hauptverfasser:	Zervides, Kristoffer A, Janelidze, Shorena, Nystedt, Jessika, Gullstrand, Birgitta, Nilsson, Petra, Sundgren, Pia C, Bengtsson, Anders A, Hansson, Oskar, Jönsen, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Analysis Anti-DNA antibodies Antibodies Biological markers Biomarker Cerebrospinal fluid Clinical Medicine Cognition Cognitive ability Complement component C3 Complications and side effects Correlation analysis Creatinine Cross-Sectional Studies Cytoplasmic filaments Development and progression Diagnosis Female Guillain-Barre syndrome Headaches Health aspects Humans Immunology Klinisk medicin Laboratories Lupus Lupus Erythematosus, Systemic - complications Lupus Vasculitis, Central Nervous System - diagnosis Magnetic Resonance Imaging Medical and Health Sciences Medicin och hälsovetenskap Nervous system Nervous system diseases Neurofilament light Neurologi Neurological diseases Neurology Neurons Neuropsychiatric Normal distribution Plasma Psychosis Reumatologi och inflammation Rheumatology Rheumatology and Autoimmunity Risk factors Standard scores Systemic lupus erythematosus
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Zusammenfassung:	Neuronal damage in systemic lupus erythematosus (SLE) is common, but the extent and mechanisms are unclear. Neurofilament light (NfL) concentrations rise in plasma and cerebrospinal fluid (CSF) during neuronal damage in various neurological disorders. In this cross-sectional study, plasma and CSF concentrations of NfL were explored as a marker of neuronal damage in SLE. Seventy-two consecutive SLE out-patients and 26 healthy controls, all female, aged
ISSN:	1471-2377 1471-2377
DOI:	10.1186/s12883-022-02998-3