Assessment of the Association of Vitamin D and the Risk of Tuberculosis among End-Stage Kidney Disease Population

We investigated the role of vitamin D in the risk of tuberculosis (TB) among patients with end-stage kidney disease (ESKD). The retrospective cohort was conducted with data of 20,985 patients with kidney disease and 20,985 controls without kidney disease (1:1 matching on age of cohort entry and sex)...

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Veröffentlicht in:Life (Basel, Switzerland) Switzerland), 2022-11, Vol.12 (11), p.1881
Hauptverfasser: Dlamini, Sithembiso Tiyandza, Htet, Kyaw Moe, Theint, Ei Chue Chue, Li, Wei-Ming, Chang, Hsin-Wen, Tu, Hung-Pin
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Sprache:eng
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Zusammenfassung:We investigated the role of vitamin D in the risk of tuberculosis (TB) among patients with end-stage kidney disease (ESKD). The retrospective cohort was conducted with data of 20,985 patients with kidney disease and 20,985 controls without kidney disease (1:1 matching on age of cohort entry and sex) in the duration of 1997−2010 from the Taiwan National Health insurance database. Then, by a case−cohort study, among 20,985 kidney disease, 3194 ESKD patients were identified with matched 3194 non-ESKD patients. Multivariate analyses revealed a significant association between kidney disease and tuberculosis (adjusted incidence rate ratio (IRR) 1.57 (1.33−1.86)), and the risk increased after 3 years of follow-up the (adjusted IRR 3.79 (2.55−5.62)), but after more years of follow-up no significance was observed. We also found that ESKD increases the risk of tuberculosis (adjusted IRR 3.67 (2.27−5.93)). However, vitamin D usage was not related with the tuberculosis risk in ESKD patients (p > 0.1783). Our study showed increased risk of tuberculosis in kidney disease and ESKD patients, and vitamin D was not beneficial in ESKD.
ISSN:2075-1729
2075-1729
DOI:10.3390/life12111881