Terpenoids from the Roots of Stellera chamaejasme (L.) and Their Bioactivities

An undescribed diterpene, stellerterpenoid A ( ), and two undescribed sesquiterpenoids, stellerterpenoids B and C ( - ), together with six known compounds, prostratin ( ) stelleraguaianone B ( ), chamaejasnoid A ( ), auranticanol L ( ), wikstronone C ( ), and oleodaphnone ( ), were isolated from the roots of L. Their structures were elucidated by extensive spectroscopic data (1D, 2D NMR, IR, UV, and HR-ESI-MS). The absolute configuration of - was elucidated based on ECD calculation. Among them, stellerterpenoid A was a rare 13, 14-seco nortigliane diterpenoid and stellerterpenoid B was a guaiacane-type sesquiterpenoid with an unusual 1, 2-diketone moiety. The known stelleraguaianone B ( ) exhibited moderate activity for suppressing NO production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages cells with an IC value of 24.76 ± 0.4 μM. None of the compounds showed anti-influenza virus or anti-tumor activity in vitro.