Subjective cognitive decline domain improves accuracy of plasma Aβ42/Aβ40 for preclinical Alzheimer's disease diagnosis: The SILCODE study

[...]both PET scans and CSF analyses are expensive, hampering their use in large-scale screening. [...]blood-based biomarkers are desirable alternatives, as they are cost-effective and not invasive. Blood sample collection, storage, and analysis of the plasma Aβ42/Aβ40 ratio and amyloid-PET (AV45-PET) and MRI acquisition parameters, processing methods, calculation and analysis of standard uptake value rate (SUVR) values are shown in Supplementary Materials, http://links.lww.com/CM9/B722. Partial correlation analysis, which was controlled for age, sex, and education, showed a significantly negative association between global gray matter volume and SUVR (ρ = –0.225, P = 0.039) [Figure 1D], while no association was found between hippocampal volumes and SUVR (ρ = 0.343, P >0.1). [...]our results suggest that the plasma Aβ42/Aβ40 ratio could reflect central amyloid AD pathology in cognitively normal elderly Chinese subjects, especially when combined with SCD characteristics and neurodegenerative biomarkers.