The properties of MOF-Zn2(EBNB)2(BPY)2·2H2O and its basic study of loading methadone

The ligands of (E)-bis(p-3-nitrobenzoic acid) vinyl (C 16 H 10 N 2 O 8 ) were synthesized in three steps, and then the MOF-Zn 2 (EBNB) 2 (BPY) 2 ·2H 2 O was synthesized by solvothermal method. This structure was characterized by X-ray single crystal diffraction, SEM and TG. The drug loading and in vitro release of Zn 2 (EBNB) 2 (BPY) 2 ·2H 2 O were also studied with Methadone as model drug. The results show that the highest loading amount of Zn 2 (EBNB) 2 (BPY) 2 ·2H 2 O to Methadone was 0.256 g/g, and the drug delivery system was a two-phase mode. The results of in vitro cytotoxicity test show that Zn 2 (EBNB) 2 (BPY) 2 ·2H 2 O has good biocompatibility.