Cytokine levels and pathological characteristics of a patient with severe coronavirus disease 2019: a case report

Laboratory tests revealed that the IL-6 and IL-10 levels were increased (345.51 and 44.77 pg/mL, respectively). [...]CD4+ T cell count was 147 cells/μL, and CD8+ T cell count was 114 cells/μL. Also, the lymphocyte count decreased. [2] The next day, he experienced sudden decreases in his blood pressure and blood oxygenation level, and chest computed tomography images showed right hemopneumothorax. [5] The study showed the presence of increased cytokine levels (IL-6 and IL-10) and lymphopenia (CD4+ and CD8+ T cells) in individuals with severe COVID-19. Funding This work was supported by grants from the National Natural Science Foundation of China (Nos. 81770276, 81772045, and 81902000), Novel coronavirus pneumonia emergency treatment and diagnosis technology research project of Heilongjiang Provincial Science and Technology Department, Nn10 program of Harbin Medical University Cancer Hospital and Scientific research project of Heilongjiang health and Family Planning Commission (No. 2018086).