Expression of immune checkpoint on subset of monocytes in old patients

Expression of immune checkpoint on subset of monocytes in old patients

Immune checkpoints and their ligands are important actors of lymphocytes and monocytes activation's regulation. Their expression level within T cells changes with aging. Despite the major impact of aging on monocytes, there is no data about the expression of ICs on monocytes from old patients....

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Veröffentlicht in:Experimental gerontology 2023-10, Vol.181, p.112267-112267, Article 112267
Hauptverfasser: Royer, Luca, Chauvin, Manon, Dhiab, Jamila, Pedruzzi, Eric, Boddaert, Jacques, Sauce, Delphine, Vallet, Hélène
Format: Artikel
Sprache:eng
Schlagworte:
Immune checkpoint
Life Sciences
Monocytes
Older
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Zusammenfassung:Immune checkpoints and their ligands are important actors of lymphocytes and monocytes activation's regulation. Their expression level within T cells changes with aging. Despite the major impact of aging on monocytes, there is no data about the expression of ICs on monocytes from old patients. The objective of our study is to describe the expression of ICs and their ligands on monocytes from young individuals compared to old patients. We included 18 old control (>75 years old), 10 young control (
ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2023.112267