Perioperative management in a case of glucose-6-phosphate dehydrogenase deficiency undergoing orthopaedic surgery

Various drugs used for anesthesia and analgesia, antibiotics, surgical stress, infection, conditions associated with generation of free radicals like perioperative ischemia, reperfusion, hypothermia and acidosis are known to cause oxidative stress and thereby hemolysis in G6PD deficient patient. Young age, male gender, negative family history of G6PD deficiency, presence of fever and vomiting and high alkaline phosphatase are the predictors for severe hemolysis [2] as in this case.