Gait disorders in CKD patients: muscle wasting or cognitive impairment? A cross-sectional pilot study to investigate gait signatures in Stage 1-5 CKD patients

Instrumental gait analysis in nephrology is widely neglected, although patients with chronic kidney disease (CKD) show brain changes due to cerebrovascular disease and metabolic disorders that can potentially influence gait quality. Our study assesses the association between CKD stages and gait para...

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Veröffentlicht in:BMC NEPHROLOGY 2022-02, Vol.23 (1), p.72-10, Article 72
Hauptverfasser: Zemp, Damiano D, Giannini, Olivier, Quadri, Pierluigi, Rabuffetti, Marco, Tettamanti, Mauro, de Bruin, Eling D
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Sprache:eng
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Zusammenfassung:Instrumental gait analysis in nephrology is widely neglected, although patients with chronic kidney disease (CKD) show brain changes due to cerebrovascular disease and metabolic disorders that can potentially influence gait quality. Our study assesses the association between CKD stages and gait parameters, to understand the prevalent status of brain related gait parameters (i.e. variability) and of performance related parameters (i.e. gait speed, stride length). We hypothesize that gait changes are detectable already in early stages of CKD. Forty-five participants distributed in 5 CKD severity groups underwent an instrumental gait analysis via a triaxial accelerometer affixed to the lower trunk under single- and dual-task conditions. In addition to spatio-temporal parameters, variability and dual-task cost of gait were extracted. A battery of clinical assessments was conducted with the aim of helping to better explain the findings of the gait analysis. A correlation analysis was made to investigate a linear relation between gait parameters and CKD severity. Statistically significant correlations (Pearson correlation coefficient) with CKD severity were found for gait speed (p 
ISSN:1471-2369
1471-2369
DOI:10.1186/s12882-022-02697-8