Lipid metabolism analysis providing insights into nonylphenol multi-toxicity mechanism

Nonylphenol (NP), a widely recognized endocrine disruptor, exhibits lipophobic properties that drive its accumulation in adipose tissue, leading to various physiological disruptions. Using Caenorhabditis elegans, this study investigated the effects of NP exposure on lipid homeostasis and physiological indicators. NP exposure increased lipid storage, hindered reproduction and growth, and altered phospholipid composition. Transcriptional analysis revealed NP’s promotion of lipogenesis and inhibition of lipolysis. Metabolites related to lipid metabolism like citrate, amino acids, and neurotransmitters, along with lipids, collectively influenced physiological processes. This work elucidates the complex link between lipid metabolism disturbances and NP-induced physiological disruptions, enhancing our understanding of NP’s multifaceted toxicity. [Display omitted] •NP induced increased lipid accumulation and disrupted physiology of C. elegans•NP altered lipid profiles, especially phosphatidylcholines and fatty acids•NP stimulated lipogenesis and inhibited lipolysis•Upregulated citramalic acid, amino acids linked to lipid deposition Biochemistry; Lipid; Toxicology