Differences in clinicopathological characteristics, treatment, and survival outcomes between older and younger breast cancer patients

In developing countries, breast cancer is diagnosed at a much younger age. In this study we investigate the dichotomies between older and young breast cancer patients in our region. The study involved two cohorts; older patients (≥ 65 years, n = 553) and younger ones (≤ 40 years, n = 417). Statistic...

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Veröffentlicht in:Scientific reports 2021-07, Vol.11 (1), p.14340-14340, Article 14340
Hauptverfasser: Abdel-Razeq, Hikmat, Iweir, Sereen, Abdel-Razeq, Rashid, Rahman, Fadwa Abdel, Almasri, Hanan, Bater, Rayan, Taqash, Ayat, Abdelkhaleq, Hadeel
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Sprache:eng
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Zusammenfassung:In developing countries, breast cancer is diagnosed at a much younger age. In this study we investigate the dichotomies between older and young breast cancer patients in our region. The study involved two cohorts; older patients (≥ 65 years, n = 553) and younger ones (≤ 40 years, n = 417). Statistical models were used to investigate the associations between age groups, clinical characteristics and treatment outcomes. Compared to younger patients, older patients were more likely to present with advanced-stage disease (20.6% vs. 15.1%, p  = .028). However, among those with non-metastatic disease, younger patients tended to have more aggressive pathological features, including positive axillary lymph nodes (73.2% vs. 55.6%, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-93676-w