TRAF6 as a potential target in advanced breast cancer: a systematic review, meta-analysis, and bioinformatics validation

TRAF6 has emerged as a key regulator of breast cancer (BCa). However, the TRAF family constitutes of seven members that exhibit distinct and overlapping functions. To explore which TRAF represents a potential druggable target for BCa treatment, we searched Medline, Web of Science and Scopus for rele...

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Veröffentlicht in:	Scientific reports 2023-03, Vol.13 (1), p.4646-4646, Article 4646
Hauptverfasser:	Zeng, Feier, Carrasco, Giovana, Li, Boya, Sophocleous, Antonia, Idris, Aymen I.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/555 631/67 631/67/1059/153 631/67/1344 631/67/1347 Animal models Animals Bioinformatics Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cell adhesion Cell culture Cell migration Female Humanities and Social Sciences Humans Inhibitors Meta-analysis Metastases Mice multidisciplinary Patients Science Science (multidisciplinary) TNF Receptor-Associated Factor 2 - metabolism TNF Receptor-Associated Factor 6 - antagonists & inhibitors TNF Receptor-Associated Factor 6 - genetics TRAF2 protein TRAF6 protein Tumors Ubiquitin-Protein Ligases - metabolism
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Zusammenfassung:	TRAF6 has emerged as a key regulator of breast cancer (BCa). However, the TRAF family constitutes of seven members that exhibit distinct and overlapping functions. To explore which TRAF represents a potential druggable target for BCa treatment, we searched Medline, Web of Science and Scopus for relevant studies from inception to June 27, 2021. We identified 14 in vitro, 11 in vivo and 4 human articles. A meta-analysis of pharmacological studies showed that in vitro inhibition of TRAF2/4 (mean difference (MD): − 57.49, 95% CI: − 66.95, − 48.02, P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-023-31557-0