The relationship of cholecalciferol and parathyroid hormone with metabolic disorders in patients with arterial hypertension

Background. Essential hypertension (EH) is a complex, multifactorial and polygenic disease. Despite effective measures for control and modification of traditional risk factors, a significant amount of risk remains. The aim of the study was to evaluate changes in clinical parameters and to analyze the relationship of cholecalciferol, parathyroid hormone with anthropometric, metabolic parameters in patients with EH. Materials and methods. One hundred subjects with EH and target organ damage (stage 2), moderate, high, very high cardiovascular risk were enrolled in case-control study. Control group consisted of 60 healthy subjects matched for sex and age. Pearson’s test was used to determine the relationship between parameters in case of categorical variables; analysis of variance (ANOVA) when one of the variables is categorical and the other is numerical (interval); non-parametric Kruskal-Wallis test in case of abnormal array distribution. Results. Development and course of EH is characterized by clinical, hemodynamic, metabolic abnormalities that are nonlinearly exacerbated with the severity of hypertension. Correlation analysis showed a direct relationship between body weight and waist-to-hip ratio (r = 0.76–0.88; р