Differences in Expression Levels of Haemopoietic Factors in Serum and Bone Marrow before and after Chemotherapy in Patients with Acute Myeloid Leukemia at Different Altitudes and Their Significance

Background Chemotherapy is a crucial treatment for patients with acute myeloid leukemia (AML), with bone marrow suppression as the most common toxic side effect. The development, proliferation, and differentiation of various types of blood cells are regulated by a variety of hematopoietic factors. However, it is not clear whether there is a difference in the expression level of hematopoietic factors after chemotherapy in patients with AML at different altitudes and the change pattern has not been clarified. Objective To investigate whether there are differences in the expression levels of hematopoietic factors in bone marrow and serum before and after chemotherapy and their changes in patients with AML at varying altitudes. Methods A total of 28 AML patients (non-M3 type) treated for the first time in the Department of Hematology at Qinghai Provincial People's Hospital (1 501 to 2 500 m in the middle altitude area) and the Department of Hematology of Xi-Jing Hospital, Air Force Medical University of PLA (500