Genetic variant rs10251977 (G>A) in EGFR-AS1 modulates the expression of EGFR isoforms A and D

Tyrosine kinase inhibitor is an effective chemo-therapeutic drug against tumors with deregulated EGFR pathway. Recently, a genetic variant rs10251977 (G>A) in exon 20 of EGFR reported to act as a prognostic marker for HNSCC. Genotyping of this polymorphism in oral cancer patients showed a similar...

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Veröffentlicht in:	Scientific reports 2021-04, Vol.11 (1), p.8808-8808, Article 8808
Hauptverfasser:	Dhamodharan, Shankar, Rose, Mathew Maria, Chakkarappan, Sundaram Reddy, Umadharshini, Karuppiah Vijayamuthuramalingam, Arulmurugan, Ramalingam, Subbiah, Shanmugam, Inoue, Ituro, Munirajan, Arasambattu Kannan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208 631/337 631/67 692/4028 Alternative splicing Antisense Elements (Genetics) - genetics Binding sites Cell Line, Tumor Enzyme inhibitors Epidermal growth factor receptors ErbB Receptors - genetics Genetic diversity Genetic variance Genetic Variation Genotype Genotyping Head & neck cancer Humanities and Social Sciences Humans Isoforms Kinases Mouth Neoplasms - genetics multidisciplinary Oral cancer Polymorphism Protein Isoforms - genetics Protein-tyrosine kinase Science Science (multidisciplinary) Squamous cell carcinoma Tumors
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Zusammenfassung:	Tyrosine kinase inhibitor is an effective chemo-therapeutic drug against tumors with deregulated EGFR pathway. Recently, a genetic variant rs10251977 (G>A) in exon 20 of EGFR reported to act as a prognostic marker for HNSCC. Genotyping of this polymorphism in oral cancer patients showed a similar frequency in cases and controls. EGFR-AS1 expressed significantly high level in tumors and EGFR-A isoform expression showed significant positive correlation (r = 0.6464, p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-88161-3