Kidney Drug Transporters in Pharmacotherapy

The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug-drug int...

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Veröffentlicht in:	International journal of molecular sciences 2023-02, Vol.24 (3), p.2856
Hauptverfasser:	Łapczuk-Romańska, Joanna, Droździk, Maria, Oswald, Stefan, Droździk, Marek
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Acids Carrier Proteins - metabolism Creatinine DNA methylation Drug Interactions Drug therapy drug transporters Drug-Related Side Effects and Adverse Reactions - metabolism Glucose Humans kidney Kidney - metabolism Kidney diseases Kidneys Membrane Transport Proteins - metabolism Metabolites Organic Anion Transporters - metabolism Pharmacology Phosphorylation Protein expression Protein transport Proteins Review Therapeutic targets Toxins Tumor necrosis factor-TNF
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Beschreibung
Zusammenfassung:	The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug-drug interactions, as well as constituting direct drug targets. The above aspects of kidney transport proteins are discussed in the review.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms24032856