Colonic Metastasis of Renal Cell Carcinoma with Sarcomatoid Differentiation

Renal Cell carcinoma (RCC) can metastasize to any site in the body but metastasis to Gastrointestinal Tract (GIT) is extremely rare. Sarcomatoid RCC (sRCC), an aggressive subclone can be seen in variable proportions with other histological subtypes of RCC and is metastatic in majority of the cases. However, sRCC in association with primary papillary carcinoma metastasizing to colon is very rare, to the best of authors’ knowledge has never been reported before. Colonic metastasis of RCC is challenging for both the clinician and pathologist. We hereby present a case of 33-year-old female, a known patient of renal cell carcinoma with left nephrectomy done 3 years back, who presented with a descending colonic mass.