A new antimicrobial compound from the leaves of Dodonaea viscosa for infectious diseases

The main aim of this research work was to isolate and characterize the antimicrobial compounds that can be extracted from the leaves of Dodonaea viscosa (D. viscosa) and to assess their antimicrobial potency by established in-vitro agar diffusion method. The methanol extract was liquefied and fractioned by using a separatory funnel and organic solvents having different polarities. The agar diffusion technique was used to assess the antimicrobial potency of extracts and pure compounds against 5 g (+and -) microbial strains. Antimicrobial potency results showed that all extracts and isolated pure compounds provided significant antimicrobial potency against the applied microbial strains. The highest activity chloroform extract was analysed by column chromatography (CC) for the isolation of antimicrobial compounds. The structure of the isolated compounds was characterized based on 1D, 2D NMR and MS spectra. In conclusion, purest compounds might be useful as a remedy for infectious diseases. The compound 3, 5, 7, 3′,4′-pentahydroxyflavone (1) and as 6-hydroxy-5, 8, 9-trimethyl-18-carboxylclerodane (2) were isolated from the leaves of Adenium ob Dodonaea viscosa. The isolated compounds were report first times from the active chloroform crude extract of D. viscosa. [Display omitted] •Dodonaea viscosa is used traditionally in Oman to treat rheumatism, gout, and aches.•The antimicrobial activity of extracts and compounds was evaluated by diffusion method.•The highest active extract was used to isolate antimicrobial compounds.•The compounds were isolated for the first time from the selected Omani species.•The extract and compound could be used as antibities for infectous diseases.